Biologics Discovery Consulting

Early-Stage Biologics.
From Target to Lead.

Expert consulting across the full discovery arc — computational protein design, assay development, screening, protein engineering, and laboratory operations. Productive on day one.

Michael Minson, PhD

Principal — Minimal Bio
  • PhD Biochemistry — CU Boulder
  • 14yr R&D experience
  • 1,000+ Engineered variants screened
  • $8.9M Seed round supported
  • 5→15 R&D team scaled
Discovery Workflow
01 Target Selection
02 Computational Design
03 Assay Development
04 Screening & Characterization
05 Lead Optimization
How I Can Help

One scientist across
the full discovery stack.

Most consultants specialize in one piece of the pipeline. I operate across the full early discovery arc — from computational design through screening and lead optimization — because I've done each of these jobs at the bench. That means fewer handoffs, faster iteration, and someone who understands how upstream decisions affect downstream outcomes.

Services

Specialized expertise, available on your timeline.

Wet Lab

Assay Development & Screening

Functional assay design, high-throughput screening strategy, and hit-to-lead triage. Live-cell, biochemical, and binding assays.

Protein Science

Protein Engineering & Production

Expression system selection, purification optimization, variant library design, and biophysical characterization.

Operations

Laboratory Operations

Lab build-out, equipment sourcing, automation strategy, protocol optimization, and team scaling for early-stage teams.

Ongoing

Embedded Partnership

I work as an extension of your team across any combination of the above. Productive on day one.

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Background

From bench to binder — and everything in between.

14 years building discovery platforms, engineering proteins, and developing assays in startup and academic environments. I added computational protein design to solve a specific pain point — generating novel binders with freedom to operate — and now bring that capability alongside everything else.

Discovery & Screening

High-throughput screening platforms, live-cell functional assays with Z' > 0.9, automated workflows evaluating 1,000+ engineered variants. I've built these systems from scratch.

Computational Design

Integrated platform coupling generative protein design, structure prediction, and developability optimization. I bring the wet lab expertise that every computational pipeline needs.

Startup Velocity

Built discovery platforms from zero, contributed to an $8.9M seed round, and scaled R&D from 5 to 15 scientists. I work at the pace early-stage teams need.

Ready to accelerate your program?

Let's discuss how I can help you reach your next milestone faster.

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