Services

Expert consulting from discovery to scale

Computational Protein Design

Novel binders — designed to work at the bench.

Core Capability

Target-to-Binder

You provide a protein target. I deliver ranked, developability-optimized binder candidates with structural models and synthesis-ready sequences. My platform couples state-of-the-art generative design with biologically informed refinement at every stage — because I've been on the other side of the handoff, screening computationally designed proteins at the bench.

What's Included

  • Target surface analysis, epitope mapping, and binding site characterization
  • De novo binder scaffold generation using leading generative models
  • Multi-round sequence optimization with developability scoring
  • Structure prediction and validation against target complex
  • Developability screening and optimization — solubility, stability, and expression likelihood evaluated at every stage
  • Ranked candidate report with full structural data, confidence metrics, and interface analysis
  • Synthesis-ready sequences and recommended screening strategy

I design the sequences, you keep the IP.

Sample Design Report Sample Binder Report Pricing Guide
Build Capability

Pipeline Consulting

I help your team stand up, validate, and optimize an internal computational protein design capability. This engagement transfers both the technical infrastructure and the practical knowledge required to operate an effective design pipeline — including the biological judgment layer that separates raw model output from experimentally viable candidates.

What's Included

  • Hardware and GPU infrastructure assessment
  • Tool selection, installation, and environment configuration
  • Pipeline architecture — connecting generative models, sequence optimizers, structure predictors, and scoring tools into a reproducible workflow
  • Implementation of developability filtering and quality gates
  • Validation benchmarking against known binder/target pairs
  • SOPs, documentation, and team training

Best suited for: Teams building long-term computational design capability who want expert guidance to compress months of setup into weeks.

Sample Scope Document
Assay Development & Screening

Assays that work. Screens that find hits.

Functional Assay Design

I design, optimize, and validate functional assays for biologics discovery — from biochemical binding assays through live-cell phenotypic screens. My assays are built for reproducibility and throughput, with Z' scores routinely exceeding 0.9.

Capabilities

  • Live-cell functional assay design and optimization
  • Biochemical and binding assay development (SPR, BLI, ELISA)
  • High-throughput screening strategy and execution planning
  • Hit identification, confirmation, and triage
  • Counter-screening and selectivity panel design
  • Assay transfer and documentation for internal teams

Best suited for: Teams entering screening campaigns who need robust assays that generate trustworthy data from day one.

Protein Engineering & Production

From sequence to purified protein.

Protein Engineering & Production Consulting

I help teams navigate the practical challenges of producing and characterizing protein therapeutics — expression system selection, purification development, variant library design, and biophysical assessment. My experience spans E. coli, mammalian, and cell-free systems.

Capabilities

  • Expression system evaluation and optimization
  • Purification strategy development
  • Variant library design for directed evolution and saturation mutagenesis
  • Biophysical characterization strategy (DSF, SEC-MALS, DLS)
  • Developability assessment and manufacturability review
  • Troubleshooting expression, solubility, and stability challenges

Best suited for: Teams producing proteins for screening, characterization, or early development who need practical expertise to avoid common pitfalls.

Laboratory Operations

Build capable labs without unnecessary cost.

Lab Setup & Operations Consulting

I help early-stage biotech teams build and operate molecular biology laboratories that are efficient, maintainable, and scaled to real needs — not vendor wishlists. This is where Minimal Bio started, and the first-principles approach applies to everything: understand the system, remove what isn't required, build for reliability.

Capabilities

  • Laboratory layout and workflow design
  • Equipment sourcing — fit-for-purpose selection and vendor negotiation
  • Protocol optimization and reduction to essential steps
  • Automation strategy and roadmap (OT-2, Qpix, custom)
  • SOP development and knowledge transfer
  • Team scaling and hiring strategy for R&D operations

Best suited for: Pre-seed through Series A teams establishing or optimizing in-house laboratory capability.

Embedded Partnership

An extension of your team.

Collaborative Engagement

For teams that need ongoing support across multiple areas, I operate as an embedded partner — working alongside your scientists on whatever combination of computational design, assay development, protein engineering, and operations the program requires. I adapt to your workflow, your tools, and your pace.

How It Works

  • Flexible scope covering any combination of services above
  • Standing weekly or biweekly strategy meetings
  • Iterative design and screening cycles aligned to your timeline
  • Direct integration with your team's communication and data systems
  • Monthly reporting and milestone tracking

Productive on day one. I've operated in this model before and it's where I do my best work.

Sample Engagement Overview Pricing Guide

Let's scope your project.

Whether you need designed binders, screening support, or a full embedded partnership — I'd welcome the conversation.

Get in Touch